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TUMOR NECROSIS FACTOR-ALPHA
Descriptors Found:
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DeCS
Descriptor
English
:
Tumor Necrosis Factor-alpha
Descriptor
Spanish
:
Factor de Necrosis Tumoral alfa
Descriptor
Portuguese
:
Fator de Necrose Tumoral alfa
Synonyms
English
:
Cachectin
TNF-alpha
Tumor Necrosis Factor Ligand Superfamily Member 2
Tree Number:
D12.644.276.374.500.800
D12.644.276.374.750.626
D12.644.276.972.626
D12.776.124.900
D12.776.395.930
D12.776.467.374.500.800
D12.776.467.374.750.626
D12.776.467.972.626
D23.529.374.500.800
D23.529.374.750.626
D23.529.972.626
Definition
English
:
Serum glycoprotein produced by activated
MACROPHAGES
and other mammalian MONONUCLEAR
LEUKOCYTES
. It has necrotizing activity against tumor cell lines and increases ability to reject tumor
transplants
. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
History Note
English
:
2005(1988)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
29591
Unique Identifier:
D014409
Occurrence in VHL
:
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